NAD+: Production, effect and shelf life of lyophilisate compared to solutions and concentrates

The production, effect and shelf life of lyophilisates in contrast to solutions and concentrates is an exciting topic, especially in connection with NAD+ (nicotinamide adenine dinucleotide). Here is a discussion on this:

Production of lyophilisates

Lyophilization, also called freeze-drying, is a process in which a product is frozen and then the frozen water is sublimated under vacuum. This means that the water goes directly from the solid to the gaseous state without becoming liquid. The process takes place in three main steps:

1. Freezing : The product is brought to very low temperatures to stabilize it.
2. Primary drying : Under vacuum, most of the water is removed by sublimation.
3. Secondary drying : Removes the remaining, tightly bound water to increase stability.

Effect

Lyophilisates are extremely stable and retain their biochemical properties over a longer period of time. Since they do not contain any liquid water content, they are less susceptible to microbial growth and enzymatic reactions that could affect the effectiveness of the product. In the case of NAD+, the maintenance of biological activity is crucial because it acts as a coenzyme in many important biochemical reactions in the body, especially in energy metabolism.

durability

Lyophilisates have a significantly longer shelf life compared to liquid solutions and concentrates. The absence of water minimizes hydrolytic degradation processes and oxidation reactions. When stored correctly (cool and dry), lyophilisates can remain stable for months to years, while solutions and concentrates often only have a shelf life of a few weeks to months because they are more susceptible to chemical and microbiological changes.

Comparison with solutions and concentrates

• Solutions : They are easy to handle and ready to use. However, they are sensitive to temperature and light fluctuations and tend to lose their effectiveness more quickly.
• Concentrates : Offer greater stability than solutions because they contain less water, but are still less stable than lyophilisates. They often require special storage conditions and have a limited shelf life.

Why our NAD+ is a lyophilisate

Our NAD+ is offered as a lyophilisate to ensure maximum stability and potency. NAD+ is a delicate molecule whose biological activity can rapidly decrease if stored under non-optimal conditions. Lyophilization keeps NAD+ in a stable, dry state, minimizing degradation from chemical reactions and microbial contamination.

In summary, the choice of lyophilization for NAD+ is due to the need for long-term stability and preservation of biological activity. This makes lyophilisates the ideal form for sensitive and vital molecules such as NAD+, which play a crucial role in research and medicine.