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Repairing DNA damage is essential to maintaining the stability of our genome and our health. A crucial player in this process is NAD+ (nicotinamide adenine dinucleotide), a coenzyme that supports many cellular functions, including DNA repair.
NAD+ is essential for the activity of enzymes involved in DNA repair, particularly poly-ADP-ribose polymerases (PARPs). These enzymes use NAD+ as a substrate to synthesize poly-ADP-ribose chains that bind to damaged DNA. This process signals other repair proteins that DNA damage is present and needs to be repaired. Without sufficient NAD+, PARPs are less effective, impairing the cell's ability to detect and repair DNA damage.
Adequate availability of NAD+ helps reduce the accumulation of DNA damage. This damage can be caused by environmental factors such as UV radiation, smoking and pollution, as well as by normal cellular metabolism. NAD+ supports the efficient repair of this damage, thus reducing the risk of mutations and their potential negative effects.
By promoting DNA repair, NAD+ helps prevent cellular aging and the development of diseases caused by genetic damage. Inadequately repaired DNA damage can lead to cellular aging and programmed cell death (apoptosis). In the long term, this can contribute to the development of age-related diseases such as cancer and neurodegenerative diseases. NAD+ therefore plays a protective role by preserving the integrity of DNA and promoting cellular health.
Efficient DNA repair is crucial for the survival and proper functioning of cells. NAD+ helps cells maintain their genetic integrity, which is essential for the overall health and well-being of the organism. Healthy cells can perform their tasks effectively, which has a positive effect on the entire body system.
NAD+ is an essential factor in DNA repair and plays an important role in maintaining genome stability and cellular health. By supporting repair enzymes such as PARPs, reducing DNA damage, preventing cell aging and disease, and promoting cell survival and function, NAD+ makes a crucial contribution to overall health and well-being. Sufficient availability of NAD+ can therefore have a significant impact on longevity and quality of life. Stay up to date and find out how you can optimize your NAD+ levels - your cells will thank you!
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